Gamboa made his professional boxing debut on April 27, 2007, in Hamburg, Germany against Alexan Manvelyan. Gamboa put Manvelyan on the canvas in the third round and beat up his foe throughout the fight for the unanimous decision victory. Two months later, he defeated Araik Sachbazjan by fourth round technical knockout. After winning his next four fights, Gamboa made his United States debut on October 30, 2007, at the Seminole Hard Rock Hotel and Casino in Hollywood, Florida against Adailton De Jesus. De Jesus was dropped to the canvas halfway through the first round. A Gamboa slip in the fourth round was ruled a knockdown by the referee. Gamboa's relentless pressure eventually forced a stoppage in the sixth and final round.
Boxing - Yuriorkis Gamboa's US Debut vs Adailton De Jesus
Gamboa had a very dominating first round. He buzzed Mtagwa several times from several angles and scored a knockdown in the final ten seconds with a counter hook. He continued the damage in the second round, battering Mtagwa and sending him down two more times before the fight was stopped.
Gamboa also took the oportunity to proclaim his desire to fight higher caliber featherweight boxers such as Indonesian Chris john and puertorican Juan Manuel Lopez who was attending the fight as a spectator and decided to come up to the ring and proclaim his desire for a posible fight with Gamboa as he also made the observation that it was a business decision to be taken by their shared promoter Bob Arum. Both Juan Manuel Lopez and Gamboa displayed a true sportsmanship conduct as they forecasted a possible fight between them in the future.