She was very successful in women's collegiate golf in the next two years, winning the NCAA Player of the Year Awards for 2001 and 2002, finishing runner-up at both the 2001 and 2002 NCAA National Championship and being named to the National Golf Coaches Association (NGCA) 2001 All-America First team. She won the 2001 Pac-10 Women's Golf Championships, was named Pac-10 Freshman/Newcomer of the Year 2001 and was All Pac-10 First team in 2001 and 2002. In her sophomore year she had eight tournament wins in ten events she entered and set an NCAA record with seven consecutive victories in her first seven events. She won the Golfstat Cup in both 2001 and 2002. The Cup is given to the player who has the best scoring average versus par with at least 20 full rounds played during a season. setting the single-season NCAA scoring average record as a freshman at 71.33 and beating her own record the next year by just over a stroke per round with a 70.13 average. In November 2001, Ochoa was presented with Mexico's National Sports Award by Mexican President Vicente Fox. She was the youngest person and first golfer to receive Mexico's highest sporting accolade. In 2006 she was named NCAA Division I Women's Golf Most Outstanding Student Athlete, an award which was bestowed as part of the 25th Anniversary of Women's Championships celebration, taking into account outstanding performances over the past 25 years. She was the recipient of the 2003 Nancy Lopez Award, which is presented annually to the world's most outstanding female amateur golfer.
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Her achievements were recognized outside the sport of golf when Ochoa won the 2006 Associated Press Female Athlete of the Year award and received the National Sports Prize for the second time. In April 2007, Ochoa overtook Annika Sörenstam to become the world number one ranked golfer. In August 2007, Ochoa won her first major championship at the historic home of golf, the Old Course at St. Andrews, with a wire-to-wire win by four shots at the Women's British Open. She won the next two LPGA events, the CN Canadian Women's Open and the Safeway Classic, the first to win three consecutive events since Sörenstam in 2005. Also in 2007, Ochoa became the first woman ever to earn more than $4,000,000 in a single season, surpassing Sörenstam's previous record of $2,863,904. In April 2008, Ochoa won her second major championship, this time at the Kraft Nabisco Championship, becoming the first golfer to win consecutive LPGA majors since Sörenstam in 2005. She celebrated this victory in the traditional fashion for the Kraft Nabisco by jumping into the pond on the 18th green. The following week, she won the Corona Championship in her home country by 11 strokes. This gave her the final tournament win she needed to qualify for the World Golf Hall of Fame, although she cannot be inducted until 2012, after she completes ten seasons on the LPGA Tour. Ochoa is coached by Rafael Alarcon, a Mexican professional. Alarcon finished second in the 1976 Canadian Amateur Championship, won that title in 1979, then turned professional.
On April 20, 2010, Ochoa released a statement indicating her intent to retire from professional golf. At a press conference held in Mexico City on April 23, 2010, Ochoa said her last tournament would be the 2010 Tres Marias Championship to be played from April 29 through May 2. She said that her career plan had always been to play for "around ten years" and to be the number 1 ranked player in the world. She also said: "I just want to be honest with all of you. I went to Asia, and after two or three days of being in Thailand, it was really easy to me -- it was really clear to see that I didn't want to be out there, you know. I just was thinking of other things. I wanted to get home. I wanted to start working on the foundation. I wanted to be here close to my family." Ochoa said she would still maintain her membership in the LPGA and would play in the Lorena Ochoa Invitational and "I'm going to leave the door open in case I want to come back in one or two years to play a U.S. Open or a Kraft Nabisco." In November 2008, she became the host of a new annual LPGA event, the Lorena Ochoa Invitational, held at her original home course, Guadalajara Country Club. Proceeds from the tournament help support the Lorena Ochoa Foundation. Lorena Ochoa's successes fuels the family business, the Ochoa Group in Guadalajara, managed by her brother Alejandro Ochoa. Lorena Ochoa is represented by the Ochoa Sports Management, along with Alarcon and Sophia Sheridan, a Mexican golfer who plays on the LPGA's developmental tour. The Ochoas are confident the list will expand as they attempt to grow the game in Mexico through Ochoa Golf Academies, created by Lorena, Alejandro and Alarcon. Ochoa Sports Management also operates the LPGA Corona Championship, an annual tour stop in Morelia, Mexico; and the Lorena Ochoa Invitational. The Lorena Ochoa Foundation operates La Barranca, a primary school in Guadalajara with 250 underprivileged students and an innovative curriculum. In 2008, the foundation opened a high school with 21 freshmen students. The plan, according to foundation director Carmen Bolio, is to add a new class each year and then construct a high school building that's separate from the primary school. She became engaged to her boyfriend Andrés Conesa Labastida, CEO of Aeroméxico, and they married in December 2009.
Lorena Ochoa, the four-time reigning LPGA Player of the Year, said she is retiring from professional golf after an eight-year career on the top women’s tour. Ochoa, a 28-year-old from Mexico, plans to discuss details of her retirement and plans April 23 during a press conference in Mexico City, according to a statement from the Ochoa Group management agency. “Lorena gladly will share this news and the next stages of her career accompanied by sponsors, friends and family,” according to the statement. Ochoa has won 27 tournaments since 2003, including two majors, the 2008 Kraft Nabisco Championship and the 2007 Women’s British Open. Earlier this month, Ochoa disclosed plans to open a golf academy in Mira Loma, California, targeting the area’s Latino population. Ochoa’s foundation also runs a similar school in Mexico and has plans to open academies in the U.S. and other countries. Ochoa married Andres Conesa, former chief executive officer of Grupo Aeromexico SA, last year. Mexico’s largest airline is one of the golfer’s main sponsors. Lorena Ochoa got off to a solid start Thursday in a bid for her fourth consecutive victory and fifth in six starts this year. Playing for the fourth week in a row, Ochoa shot a 4-under 68 in the first round of the Ginn Open to finish a stroke behind leaders Carin Koch and Teresa Lu. Ochoa had plenty of company there, too.